ADHD and MTHFR

MTHFR gene mutation is a somewhat common cause of ADHD symptoms.

In a study of 40 kids with ADHD, researchers found that the ADHD group had significantly more MTHFR gene mutation than the control group.

The study showed that the group with ADHD had significantly more mutant A1298C allele than the control group.

A previous study by Krull has also found a relationship between A1298C mutation and the inattentiveness symptoms of ADHD.

In this same study above, 8 of 9 girls from the ADHD group were found to have A1298C mutation. Inattentiveness symptoms are more prominent in female children with ADHD.

MTHFR or methylenetetrahydrofolate reductase is the name of both a gene and an enzyme in the human body. The MTHFR genes control a biological process in the body that affects brain function. MTHFR mutations have already been linked to more than 60 disorders, including autism and mood disorders, and many individuals with ADHD.

This gene tells the body how to make the enzyme that turns folate into its bioavailable form, methyl folate, through a process called methylation. The methyl folate then converts amino acids for a variety of the body’s functions, including the manufacture of serotonin and dopamine.

This reaction involves converting homocysteine (amino acid) into methionine (another amino acid), which the body uses to make proteins and other essential compounds, such as important chemical messengers (serotonin, norepinephrine, epinephrine, dopamine, and melatonin). These brain chemicals have potent effects on mood, energy, sleep, digestion, muscle and nerve function, memory, and cognition.

When the MTHFR gene is mutated or not working, the body cannot make the enzyme properly. This can disrupt the processes down the line, including the production of serotonin and dopamine, key brain chemical players in ADHD, autism, and other mood disorders.

With the defective MTHFR gene, the body is not able to convert folate into methyl folate effectively. This can cause folic acid to build up in the bloodstream, which results in mood swings and behavioral problems. This is why folic acid supplements may harm a child with ADHD if they have this genetic defect.

This also explains, at least in part, why some individuals are sensitive or have unusual reactions to medications and even supplements. It also explains why mood and behavior can worsen when your child takes an ordinary multivitamin or even eats fortified cereals.

Activated folate or methyltetrahydrofolate (MTHF) is an integral part of the detoxification processes and inflammation regulation.

MTHFR also aids the process of detoxification in the body. When it’s not working correctly, heavy metals and minerals can reach dangerous levels or become imbalanced, which can cause hyperactivity, mood disorders, and so much more.

What are the Symptoms of MTHFR Gene Defect in ADHD?

Symptoms of MTHFR defect vary among individuals and depending on the type of mutation. Some people may have no symptoms at all; others may have more severe complications like increased risk for heart disease, sluggish detox, miscarriages in child-bearing women, and more.

Most people usually do not know that they have an MTHFR mutation unless they experience severe symptoms or undergo genetic testing.

Children with MTHFR gene mutation may be at increased risk for ADHD, learning disabilities, autism, or autoimmune disorders. However, just because one inherits the mutation does not necessarily mean they will have the problem.

Having one or two MTHFR mutations can slightly increase the levels of homocysteine present in the blood. Homocysteine is an amino acid that the body produces by breaking down dietary proteins.

High levels of homocysteine can damage blood vessels and lead to blood clots. People who have high homocysteine levels tend to have low levels of vitamin B12.

Symptoms of homocysteinemia due to MTHFR mutations include:

  • abnormal blood clotting
  • developmental delays
  • seizures
  • microcephaly
  • poor coordination
  • numbness or tingling in the hands and feet

Find out if you or your child has an MTHFR gene defect with a home personal DNA testing kit.

What is the Treatment for MTHFR Defect in Kids with ADHD?

First of all, avoid extra folic acid, the synthetic form of folate. People who have MTHFR gene defect cannot use folic acid properly and often don’t feel well after taking it.

Some with MTHFR gene mutation should avoid food fortified with synthetic vitamins, such as energy drinks, protein bars, fortified breakfast cereals, and many other processed foods. Also, many cheap drug-store brand B vitamin supplements and multivitamins contain synthetic folic acid, and therefore, they should be avoided.

Avoid the synthetic version of B12 (cyanocobalamin). Instead, use the bioactive forms (methylcobalamin, hydroxycobalamin, and adenosylcobalamin). Avoid exposure to environmental toxins and eat a clean diet wherever possible as the detoxification process is slowed with MTHFR defect.

Other forms of folate are generally better for people with MTHFR, including 5-MTHF, methyl folate, and folinic acid.

Of course, you can always get the natural folate from naturally folate-rich foods, including spinach, asparagus, chickpeas, beans, broccoli, and dark green leafy vegetables. These foods naturally contain a form of folate that is more bioavailable and generally easier for the body to use.

Methylated versions of folate (methyl folate) and vitamin B-12 (Methylcobalamin, hydroxycobalamin, or adenosylcobalamin) and biologically active form of vitamin B6 (pyridoxal-5-phosphate or P-5-P) should always be the first choice.

Thorne Methyl-Guard Plus contains active, tissue-ready forms of folate, vitamins B2, B6 and B12 for optimal absorption and brain functions.

Ok, there you have it…

I hope you find this information helpful. Let me know what you think and comment below.

Remember, ADHD does not doom your child to a life of under-achievement. You know your child is bright, full of potential, and deserves the best. In fact, many of the world’s most significant discoveries and inventions were made by people with ADHD.

I helped my crazy wild child who could not read or write when she was little with the four pillars I laid out in the Eat to Focus book. She’s now a merit scholarship student studying premed at Loyola Chicago University.

So stay strong and keep believing in your child.

Check out the Eat to Focus book to learn about my story and the four steps that I used to transform my daughter and help her reach her full potential. This information may change your child’s future.

Download your free gift “15 Quick and Simple School Day Breakfast Ideas for Kids with ADHD” before you leave.

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Anna

Clean Eating Officer (CEO) at Malama Wellness + Hypnotherapy
I'm Anna, a passionate dietitian and hypnotherapist dedicated to helping parents of kids with ADHD unlock the transformative potential of healthy eating and holistic approaches. With years of experience in pediatric nutrition and a focus on mind-body connection, I provide personalized guidance and practical tools to support positive behavioral changes and nurture your child's well-being.
I'm Anna, a passionate dietitian and hypnotherapist dedicated to helping parents of kids with ADHD unlock the transformative potential of healthy eating and holistic approaches. With years of experience in pediatric nutrition and a focus on mind-body connection, I provide personalized guidance and practical tools to support positive behavioral changes and nurture your child's well-being.